0 comments Monday, May 26, 2008

Gastroesophageal reflux disease (GERD) is described as the chronic symptoms and/or tissue damage caused by the reflux of abnormal gastric contents to the esophagus. GERD is a common disease, with associated typical symptoms of heartburn and regurgitation.

An article published in the World Journal of Gastroenterology evaluated the clinical and endoscopic features in Chinese patients with reflux esophagitis. This study was conducted by Dr. Wei Li of the Department of Gastroenterology, Beijing Friendship Hospital affiliated with the Capital Medical University.

Of 18,823 patients undergoing endoscopic examination, 1,405 (895 male and 510 female) patients were diagnosed as having reflux esophagitis, with a detection rate of 7.46% (male 9.13% and female 5.65%). The ratio of male to female patients was 1.75:1, with a significant difference. The age of onset was 15¨C89 years, with the mean age of 54.56 ¡À 14.19 years. The mean age of male and female patients was 53.82 ¡À 14.19 and 55.85 ¡À 14.08 years, respectively, with significant difference. The peak age of onset was 40¨C60 years for patients with reflux esophagitis. According to Los Angeles Classification, patients with grade A and B accounted for 90.1% of all patients. There were significant differences in the ages of patients with A and B compared with patients with grade C and D. A total of 277 patients were infected with H pylori , with a significantly decreased infection rate. Of the 1405 patients, 195 patients had associated esophageal hiatal hernia. Combination with esophageal hiatal hernia was not associated with the presence of H pylori infection and gender, but was significantly associated with the severity of esophagitis and age.

The results and conclusions demonstrated the peak age of onset was 40¨C60 years for patients with reflux esophagitis, with more male patients than female ones. The mean age of onset is lower in males than females. The infection rate of H pylori is significantly decreased in patients with esophagitis, but the severity of patients with esophagitis is not associated with H pylori infection. Old age and combination with esophageal hiatal hernia were associated with more severe esophagitis. Right esophageal mucosal damage can occur more often in patients with reflux esophagitis.

Reference: Li W, Zhang ST, ZL. Clinical and endoscopic features of Chinese reflux esophagitis patients. World J Gastroenterol 2008; 14(12): 1866-1871 http://www.wjgnet.com/1007-9327/14/1866.asp

Correspondence to: Shu-Tian Zhang, Department of Gastroenterology, Beijing Friendship Hospital affiliated with the Capital Medical University; Faculty of Gastroenterology, Capital Medical University; Beijing Digestive Disease Center, Beijing 100050, China.

About World Journal of Gastroenterology

World Journal of Gastroenterology (WJG), a leading international journal in gastroenterology and hepatology, has established a reputation for publishing first class research on esophageal cancer, gastric cancer, liver cancer, viral hepatitis, colorectal cancer, and H pylori infection for providing a forum for both clinicians and scientists. WJG has been indexed and abstracted in Current Contents/Clinical Medicine, Science Citation Index Expanded (also known as SciSearch) and Journal Citation Reports/Science Edition, Index Medicus, MEDLINE and PubMed, Chemical Abstracts, EMBASE/Excerpta Medica, Abstracts Journals, Nature Clinical Practice Gastroenterology and Hepatology, CAB Abstracts and Global Health. ISI JCR 2003-2000 IF: 3.318, 2.532, 1.445 and 0.993. WJG is a weekly journal published by WJG Press. The publication dates are the 7th, 14th, 21st, and 28th day of every month. The WJG is supported by The National Natural Science Foundation of China, No. 30224801 and No. 30424812, and was founded with the name of China National Journal of New Gastroenterology on October 1, 1995, and renamed WJG on January 25, 1998.

0 comments Monday, May 19, 2008

The symptoms of IBS and coeliac disease can often be very similar as a result the diagnosis of coeliac disease can be delayed or missed and IBS is misdiagnosed.

The new guidelines regarding the diagnosis of Irritable Bowel Syndrome (IBS) announced recently by the National Institute for Health and Clinical Excellence (NICE) could ensure this should no longer happen by introducing new diagnostic criteria, which ensures testing for coeliac disease should be undertaken before a final diagnosis of IBS is made.

Patrick Kirby, director of Xtritica, the midland based healthcare company that promotes the Biocard Celiac Test In the UK, an easy to use home screening test which can aid the detection coeliac disease within 15 minutes, says: "We very much welcome these new guidelines which will help to speed up the diagnosis of coeliac disease. Many of the symptoms are similar to those of IBS, but it is good to know that patients will now be tested automatically for coeliac disease when previously this may have been missed. Hopefully, fewer people will now have to suffer unnecessarily, often for many years, and will avoid enduring serious digestive problems and associated health problems of coeliac disease."

At least one in 100 (1) people in the UK is estimated to suffer from coeliac disease; however, according to a recent study (2), only one in eight cases is actually being diagnosed. Recent research showed that the average length of time taken for someone to be diagnosed with coeliac disease from the onset of symptoms is 13 years (3).

Coeliac disease is not a food allergy but a life long autoimmune disease caused by intolerance to gluten, a protein found in wheat, barley and rye.

For people with coeliac disease, eating gluten damages the lining of the gut, which prevents normal digestion and the absorption of food. There are serious health problems associated with coeliac disease including osteoporosis, bowel cancer and increased risk of other autoimmune diseases. The only treatment is a strict gluten-free diet for life.

Symptoms of coeliac disease range from the mild to the severe and vary between individuals; the disease can present at any stage of life. Symptoms can include bloating, abdominal pain, nausea, constipation, diarrhoea, wind, tiredness, anaemia, headaches, mouth ulcers, recurrent miscarriages, weight loss (but not in all cases), skin problems, depression, joint or bone pain and neurological (nerve related) problems.

Coeliac UK (http://www.coeliac.co.uk) charity estimates that a further 500,000 may have the disease without realising - putting them at risk of associated health problems such as osteoporosis and infertility.

There is no cure or medication for the condition so sufferers must follow a gluten-free diet in order to alleviate symptoms that include bloating, abdominal pain, nausea, constipation, diarrhoea, anaemia, headaches, mouth ulcers and damage to the gut among others.

Recently NICE (National Institute for Health and Clinical Excellence) included in its new guidelines for IBS (Irritable Bowel Syndrome) sufferers, that patients are entitled to go to their GPs for a range of blood tests to rule out other conditions, primarily coeliac disease, which is commonly misdiagnosed as IBS.

However, for ease and convenience there is now a home testing kit available that can either be dispensed within the pharmacy by a nurse or pharmacy staff or customers can self-test in the comfort of their own homes.

The Biocard Celiac test is based on a simple concept - coeliac disease is caused by intolerance to gluten. The body reacts by producing antibodies, which damage the intestine and these show up in the blood of a coeliac sufferer. The finger-prick blood test looks for certain antibodies in the blood. Results are rapid - taking just five to 10 minutes to show whether or not someone is gluten intolerant. In an independent trial (Makki, 2006), the test proved 96% accurate compared with hospital-based tests. People who receive a positive result are advised to ask their GP for further tests to confirm the diagnosis.

* Coeliac Awareness Week takes place between May 12-18, 2008. Around 1000 newly diagnosed people are joining Coeliac UK every month. For further information visit http://www.coeliac.co.uk.

Priced £19.99, the Biocard Celiac Test is distributed by Xtritica Medical and is now available from Boots and online at http://www.xtritica.co.uk

References:

1. Research quoted is from The Economic Burden of Coeliac Disease in the UK research paper
2. Research quoted is from Recent advances in Coeliac Disease by D.A. van Heel and J. West, published in Gut 2006 55, pp 1037-1046
3. Coeliac UK

http://www.coeliac.co.uk

0 comments Sunday, May 4, 2008

Johns Hopkins Health Alerts has just published a review of the new GERD guidelines, for safe, effective treatment of your acid reflux.

Treating GERD Effectively

There are four types of treatments for gastroesophageal reflux disease (GERD): lifestyle measures, medication, surgery, and endoscopic procedures.

Why it is important to treat GERD

Treating GERD is important. Untreated GERD can lead to serious complications, such as esophageal ulcers (nonhealing mucosal defects), esophageal strictures, Barrett's esophagus (a disorder of the cells lining the esophageal mucosa, which may lead to cancer), and even esophageal cancer.

Lifestyle changes to treat GERD

Doctors often recommend lifestyle changes as the first-line treatment for acid reflux. These measures can include elevating the head of the bed during sleep, not eating late at night, and avoiding alcohol or spicy foods.

New findings on effective treatments for GERD

However, a new study reported in "The Archives of Internal Medicine" (Volume 166, page 965) shows that NOT ALL of these changes are helpful in relieving GERD symptoms, and some may be unnecessarily restrictive.

Researchers looked at the results of 100 studies conducted on various lifestyle measures for GERD. Only losing weight and elevating the head of the bed showed a CLEAR BENEFIT in well-designed studies.

Other measures not found to be effective

In comparison, there was little evidence to support avoiding many suspected GERD triggers, such as alcohol, caffeine, chocolate, spicy foods, citrus, carbonated beverages, fatty foods, and mint. The same was true for sleeping on your left side or avoiding food late at night.

Although there was evidence that some of these substances and practices can cause GERD symptoms, evidence was lacking that avoiding them will relieve symptoms.

Bottom line advice on treating GERD

However, if you experience worsening GERD symptoms after eating certain foods or drinking specific beverages you should probably avoid them. In addition, you should certainly give lifestyle changes a chance before trying medication to relieve your GERD symptoms.

For the latest health alerts on GERD (acid reflux), sour stomach, and other digestive disorders, please visit the Johns Hopkins Health Alerts Digestive Disorders Topic Page at: Johns Hopkins Health Alerts Digestive Disorders

This article is exceprted from the annual Johns Hopkins White Paper: Digestive Disorders. For more information about this book, please visit: Johns Hopkins White Paper: Digestive Disorders

Johns Hopkins Health Alerts

0 comments Friday, May 2, 2008

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Foodborne diseases cause an estimated 76 million illnesses in the U.S. each year with about half associated with restaurant meals. More than 70 billion meals per year are purchased in restaurants in the U.S., accounting for 47% of total food expenditure. Therefore, preventing restaurant-associated foodborne disease is an important task of public health departments. According to an article published in the June 2008 issue of the American Journal of Preventive Medicine, the public is generally unaware of the frequency of restaurant inspections and the consequences of poor inspection results.

According to Timothy F. Jones, MD, Tennessee Department of Health and Vanderbilt University School of Medicine, "That consumers have a number of misconceptions and unrealistically high expectations of the restaurant-inspection system was a major finding of this large survey. Inspections are one mechanism through which regulatory agencies educate operators and encourage ongoing compliance. However, the industry must ultimately take responsibility for consistently and effectively maintaining food safety. Public health and regulatory agencies should work closely with the industry to improve consumers' understanding of inspection scores and the limitations of regulatory inspections, as well as the role of regulatory inspections in disease prevention."

Using data from telephone surveys of 2000 adults in Tennessee in 2006, researchers found that while almost all respondents (97%) were aware that restaurants were inspected regularly, over 50% believed that inspections occurred from 5 to more than 12 times per year. Only 33% correctly answered that the inspection frequency is twice per year. When asked how often restaurants should be inspected, even fewer people (9%) responded that restaurants should be inspected two times per year; 53% believed that inspections should occur about 12 times per year. When asked about the relative importance of inspections to protect consumers from illnesses, 70% said "very important" and 28% said it was "the most important" safety measure.

Tennessee restaurant inspectors use a 44-item checklist with a total possible score of 100 for best performance. Respondents were asked what score would be the lowest acceptable for a restaurant at which they would eat. Seventy-seven percent said a score of 80 or greater, of whom, 45% said more than 90. This contrasts to a mean score of 82 from another study of 168,000 inspections in Tennessee and where only one third of all restaurants scored higher than 90.

When asked what should happen if a restaurant did not get an acceptable score, 657 (37%) said the restaurant should be closed immediately and allowed to reopen when the situation was corrected. In Tennessee, as in many jurisdictions, it is unusual for sanctions to be imposed on an establishment based on a single inspection. Regulators work with operators to promptly mitigate risks, but closure generally follows recurrent problems that have gone uncorrected after substantial training and consultation.

The article is "Public Knowledge and Attitudes Regarding Public Health Inspections of Restaurants" by Timothy F. Jones, MD, and Karen Grimm, MA. It appears in the American Journal of Preventive Medicine, Volume 34, Issue 6 (June 2008) published by Elsevier.

Source: AJPM Editorial
Elsevier Health Sciences